I engaged Capron on the Medical College of Wisconsin’s Bioethics listserv where he confirmed to me that The Washington Post quoted him accurately. He stood behind his remarks. Capron believes that a physician who has found an off-label use of a medication to be helpful for a particular problem in a particular population has an ethical obligation to publish a research article reporting the findings to the world. He has even given a threshold outlining when the practice of medicine ends versus when the practice of unethical, non-institutional review board approved research begins. Once a physician finds a new off-label use helpful in more than two patients, he or she is engaging in unethical conduct if he or she continues treating further patients without setting up a research study. As a result, routine medicine becomes an impractical and unhelpful endeavor under these constraints, which I do not consider ethical at all. - www.psmag.com