Last year, Enzo Tagliazucchi, a postdoc at the Netherlands Institute for Neuroscience, co-led a brain-imaging study in Current Biology on LSD-induced ego dissolution, and found that the state was associated with increased connectivity between several brain areas. In explaining to me why that dissolution might be therapeutically helpful, he said that the entire psychedelic experience — even the challenging parts — has a way of “extracting the patient from his or her usual patterns of thought and contemplat[ing] upon them from a vantage point,” he explained over email. The dissolution itself seemed to play a direct role in the case of anxiety in terminal cancer patients, he added. It’s a catalyst for epiphany. “In a typical ego-dissolution experience, the user feels the boundaries between his or her body and the rest of the universe dissolve, and becomes ‘one’ with the surroundings,” he added. “This might lead to feelings of transcendence or permanence in the patients, making them realize that even after their death they will still be part of something ‘larger.’” - nymag.com