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A brief but intense period of aerobic exercise immediately reduces GABA, the main inhibitory neurotransmitter in the brain. GABA play an important role in regulating the brain’s capacity to undergo change or neuroplasticity. We observed reduced excitability of GABA-mediated networks in the motor cortex, which may explain findings from previous studies where enhanced neuroplasticity is observed after aerobic exercise. Our findings may have implications for individuals after stroke, where GABA is a promising target for promoting neuroplasticity to promote recovery of motor function. - www.psypost.org