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By analyzing MRI brain scans, Calati and her colleagues observed hippocampal volume reduction in currently depressed participants compared to the healthy control group. But they found no significant difference between those with a history of past, but not current, depression and the healthy controls. “When we compared the three groups, we found left posterior hippocampal volume reduction in currently depressed individuals when compared to healthy subjects. This reduction was not present when we compared past depressed subjects to healthy controls,” Calati explained. - www.psypost.org